09-Nov-2022 - American Chemical Society (ACS)

Beer hops compounds could help protect against Alzheimer’s disease

Beer is one of the oldest and most popular beverages in the world, with some people loving and others hating the distinct, bitter taste of the hops used to flavor its many varieties. But an especially “hoppy” brew might have unique health benefits. Recent research published in ACS Chemical Neuroscience reports that chemicals extracted from hop flowers can, in lab dishes, inhibit the clumping of amyloid beta proteins, which is associated with Alzheimer’s disease (AD).

AD is a debilitating neurodegenerative disease, often marked by memory loss and personality changes in older adults. Part of the difficulty in treating the disease is the time lag between the start of underlying biochemical processes and the onset of symptoms, with several years separating them. This means that irreversible damage to the nervous system occurs before one even realizes they may have the disease. Accordingly, preventative strategies and therapeutics that can intervene before symptoms appear are of increasing interest.

One of these strategies involves “nutraceuticals,” or foods that have some type of medicinal or nutritional function. The hop flowers used to flavor beers have been explored as one of these potential nutraceuticals, with previous studies suggesting that the plant could interfere with the accumulation of amyloid beta proteins associated with AD. So, Cristina Airoldi, Alessandro Palmioli and colleagues wanted to investigate which chemical compounds in hops had this effect.

To identify these compounds, the researchers created and characterized extracts of four common varieties of hops using a method similar to that used in the brewing process. In tests, they found that the extracts had antioxidant properties and could prevent amyloid beta proteins from clumping in human nerve cells. The most successful extract was from the Tettnang hop, found in many types of lagers and lighter ales. When that extract was separated into fractions, the one containing a high level of polyphenols showed the most potent antibiotic and aggregation-inhibiting activity. It also promoted processes that allow the body to clear out misfolded, neurotoxic proteins. Finally, the team tested the Tettnang extract in a C. elegans model and found that it protected the worms from AD-related paralysis, though the effect was not very pronounced. The researchers say that although this work may not justify drinking more bitter brews, it shows that hop compounds could serve as the basis for nutraceuticals that combat the development of AD.

Facts, background information, dossiers
  • nutraceuticals
  • hop
  • hops
  • extracts
  • university
  • amyloid beta
  • funding
  • lab
  • polyphenols
  • studies
  • plant
  • proteins
  • taste
  • beers
  • American Chemical Society
  • aggregation
More about American Chemical Society (ACS)
  • News

    Recent advances in chocolate research

    Chocolate has been appreciated as a delicacy for thousands of years, and it’s easy to see why. The luscious and luxurious treat can give you a little pick-me-up toward the end of a hard day, or provide a sweet ending to a fine meal. You might think we know everything about chocolate by now, ... more

    Toward a fully edible sensor showing if frozen food has previously thawed

    When you’re standing in the frozen food aisle, it’s nearly impossible to know whether that Salisbury steak has thawed and refrozen — a process with potentially harmful consequences. So, researchers reporting in ACS Sensors have designed a food-grade device from edible materials, including t ... more