Universitätsklinikum Tübingen, Medizinisches Proteom-Zentrum

Our main interest is on how genetic gene variants are transferred into function and how function is systemically perturbed upon disease. The goal is to study mechanisms of disease first and then to establish a basis for the development of rational strategies for therapy and prevention. Towards this goal, we rather look at protein networks than single genes or proteins and analyze their integration into a systemic physiological context. Physiology and pathophysiology can then be studied in a comparative, systematic, analytical fashion. The goal here is to learn, which critical functions on the molecular level are perturbed in neurodegenerative processes.